Archives : Sep, 2023
1. HDO Structure
HDO is composed as follows. Antisense strand (DNA, Gapmer, PMO etc.): Has a medicinal effectCarrier strand (RNA): Transport active strand (medicina
②Collaborative R&D
This is our business structure or collaborative R&D with customers, in which Rena designs and provides HDO compounds and moves collaborative R&D forw
③HDO manufacturing
This is our business structure for the HDO manufacturing business in which Rena manufactures,supplies and sells HDOs for target genes only for resear
2. HDO Mechanism of Action(1)
(RNse H-dependent antisense effect)Step 1The HDO carrier strand (RNA) incorporated into the cell is cleaved by RNase H (enzyme).Step 2The antisens
3. HDO Mechanism of Action(2)
(Splicing Control)Step 1HDO enters the cell through some special ligand into the cells.Step 2The carrier stand cleaved by RNase.Step 3The antise
4. Strengths of HDO technology
4. Strengths of HDO technology
HDO has the following strengths:By linking the ligand to the carrier strand, it is possible to selectively deliver the antisense strand to the diseas