1、 Technical introduction

(1)Structure of HDO

HDO is composed as follows.

Active strand(DNA) : Function as medicinal effect
Carrier strand(RNA) : Function as transportation of active strand (medicinal effect) to disease site
Ligand : By binding a substance that specifically binds to a specific receptor to the carrier strand, it functions as a transport to a targeted disease site

(2)The mechanism of action of HDO

The carrier strand (RNA) of HDO incorporated into the cell is cleaved by RNase H (enzyme).

The active strand (DNA) remaining after cleavage binds to the target mRNA.

When the active strand (DNA) binds to mRNA, it becomes DNA / RNA structure again, and RNase H cleaves the target mRNA.

As mRNA is cleaved, expression of mRNA is suppressed, and drug efficacy is demonstrated.

※RNase H has the property of cleaving RNA among double strands composed of DNA / RNA.

(3)Strengths of HDO technology

HDO has the following strengths.

  • By linking the ligand to the carrier strand, it is possible to selectively deliver the active strand to the diseased site, so that high efficacy can be obtained.
  • Since HDO adopts a double-stranded structure, HDO is essentially stable, it is possible to avoid toxicity by avoiding chemical modification conventionally applied to the active strand which is a medicinal part
  • Since HDO has a double-stranded structure, it becomes a materially stable structure and the enzyme resistance in blood improves
  • Since a ligand is bound to a carrier strand having a transporting function, there is a low possibility that an unexpected medicinal effect is caused depending on a ligand (if the ligand is bound to an active strand, the medicinal effect may be remarkably lowered)
  • There is no need to make the linker used for binding the ligand to the carrier strand dare to break easily
  • The position and the number of ligands bound to the carrier strand can be freely selected

2、 Business Introduction

(1)Business model

Rena have the following three business lines.


②Collaborative R&D

③HDO manufacturing

(2)business lines


This is a business form for licensing out HDO technology.


②Collaborative R&D

This is a business form of collaborative R&D with customers, in which Rena design and provide HDO compounds and advance collaborative R&D to find lead HDOs.

③HDO manufacturing

The HDO manufacturing business is a business form in which Rena manufactures, supplies and sells HDOs for target genes only for research and development.

For inquiries about the introduction of our technology