3. HDO Mechanism of Action(2)

3. HDO Mechanism of Action(2)

(Splicing Control)

  • Step 1
    HDO enters the cell through some special ligand into the cells.
  • Step 2
    The carrier stand cleaved by RNase.
  • Step 3
    The antisense strand of HDO forms a double strand with exonY of pre-mRNA, then transforms into a mature messenger RNA without exon Y.
    ※White arrow indicates mRNA produced by normal splicing in the absence of the antisense strand.